Some aspects of cellular care are so entrenched in medicine that they are almost overlooked for the miraculous cellular therapies that they are, such as stem cell transplantation to treat haematological malignancies and, of course, in vitro fertilization, life creating life. ![]() : What is the background for this study? Response: Cells are revolutionising healthcare, from modern faecal microbial transplantation in the gut to CAR-T cells fighting cancers, life healing life. But with this work we have shown for the first time that a single set of genes, a "single gene panel" can be used to discriminate between 6 broad and/or 18 specific infectious or inflammatory conditions that cause fever in children. In the past we had shown that this approach works to distinguish bacterial from viral infection, or tuberculosis disease from other conditions that mimic its symptoms. Using computational/bioinformatics methods, we are able to identify out of thousands of genes, the combinations of genes, "the biosignatures" for each disease. In our research group, we are working on novel approach instead of trying to identify the causative pathogen, which is often inaccurate or impossible, we are studying the genes in the patient's blood that are "switched on" or "switched off" during the infection or the disease in general. The available diagnostic tests are neither quick or accurate enough to fully base decisions on, such as withholding or administering antibiotics.įor example, cultures may take days or even weeks to provide a result. The identification of the cause of fever poses a great challenge for the clinical teams worldwide. : What is the background for this study? Response: Children very often present to hospital and clinics with fever, but fever is a non-specific disease symptom. In this study, we intended to test whether the MPOA can also play a part in depressive states that are linked to fluctuations in ovarian hormones. Key examples are postpartum and peri-menopausal depression. In some cases, rapid changes in the secretion of ovarian hormones can cause depressive-like symptoms. Fluctuations in the productive hormones secreted by women’s ovaries are known to cause mood swings. This result inspired us to explore whether the MPOA can play a more general role in mood regulation. : What is the background for this study? Response: Previously, we published a study in which we found that a group of neurons, namely glutamatergic neurons, in the medial preoptic area (MPOA) of the hypothalamus mediate stress-induced anxiety states. ![]() Secondly, we wanted to determine if there was a point when birthweight percentiles could get too large (i.e is there a Goldilocks effect, maybe you should not be too small but not too big either) However, we thought that this above or below the 10th percentile cut-off was unlikely to reflect the true association between birthweight percentiles and later cognitive development.įirst of all, we thought that it was unlikely that there would be a dramatic difference between someone born at the 9th vs. ![]() In long-term follow-up of at-risk infants, being born below the 10th percentile has been considered a risk factor for later cognitive development. ![]() This indicates how big the infant is relative to other infants born at the same gestational age (weeks of pregnancy). : What is the background for this study? Response: When an infant is born their birthweight percentile is often calculated. Honorary research fellow at the University of Warwick Research Associate at Universität Bielefeld
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